| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1991 | |
| Phytochemical name or plant extracts | Xanthone V | |
| PMID | 21886765 | |
| Literature evidence | In the present work, we carried out a preliminary screening of six natural compounds, xanthone V(1) (1); 2-acetylfuro-1,4-naphthoquinone (2); physcion (3); bisvismiaquinone (4); vismiaquinone (5); 1,8-dihydroxy-3-geranyloxy-6-methylQuinone (6) against MiaPaCa-2 pancreatic and CCRF-CEM leukemia cells and their multidrug-resistant subline, CEM/ADR5000. | |
| IUPAC name | methanol;5,9,10-trihydroxy-2,2-dimethyl-12-(3-methylbut-2-enyl)pyrano[3,2-b]xanthen-6-one | |
| Phytochemicals’ class or type of plant extracts | Xanthone | |
| Source of phytochemicals or plant Extracts | Vismia laurentii | |
| Geographical availability | Cameroon, Central African Repu, Congo, Zaïre | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 3, Caspase 7 | |
| Gene or Protein evidence | Caspase 3/7 was activated by xanthone V(1) | |
| Target pathways | NA | |
| IC50 | 0.56±0.06 µg/ml against MCF-7 | |
| Potency | The overall results of the present study provided evidence for the cytotoxicity of compounds xanthone V(1) and 2-acetylfuro-1,4-naphthoquinone, and bring supportive data for future investigations that will lead to their use in cancer therapy. | |
| Cell line/ mice model | CCRF-CEM, CEM/ADR5000, PF-382, HL-60, MiaPaCa-2, Capan-1, MCF-7, SW-680, 786-0, U87MG, A549, Colo-38, HeLa, Caski | |
| Additional information | The most sensitive cancer cell lines to xanthone V1 and 2-acetylfuro-1,4-naphthoquinone were Colo-38 (melanoma), HeLa and Caski (cervix cancer) with IC50 values being closer or lower those obtained with doxorubicin. In addition, MCF-7 (breast cancer) and PF-382 (leukemia) also showed high sensitivity to xanthone V1 and 2-acetylfuro-1,4-naphthoquinone respectively. | |
| PubChem ID | 139068057 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:77185673-1 | |
| Safety | NA |