| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-417 | |
| Phytochemical name or plant extracts | Xanthomicrol | |
| PMID | 33217075 | |
| Literature evidence | Our data demonstrated that xanthomicrol can induce apoptosis and suppress angiogenesis in breast cancer cells due to its inhibitory effect on oncomirs and its stimulatory effect on tumor suppressor miRNAs. © 2020 John Wiley & Sons Ltd. | |
| IUPAC name | 5-hydroxy-2-(4-hydroxyphenyl)-6,7,8-trimethoxychromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Sideritis leucantha | |
| Geographical availability | Spain | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | TNF-α, VEGF, MMP9, Ki67, Bax, Caspase 3, Caspase 9, miR21, miR27, miR125, miR29, miR34 | |
| Gene or Protein evidence | In addition, xanthomicrol reduced the expression of TNFα, VEGF, MMP9, and Ki67, while upregulating the expression of apoptotic markers such as Bax, caspase3, and caspase9. Finally, the expression of miR21, miR27, and miR125, known as oncomirs, decreased significantly after xanthomicrol administration, while the expression of miR29 and miR34, functioning as tumor suppressors, increased significantly (p < .001). | |
| Target pathways | NA | |
| IC50 | 35 μg/ml against 4T1 | |
| Potency | These data showed that the IC50 concentration of xanthomicrol could increase the percentage of both early and late apoptotic cells. The total apoptotic rate (Q2 + Q3) showed a 2.7-fold increase compared with the untreated group | |
| Cell line/ mice model | 4T1, Mouse fibroblast cells | |
| Additional information | Finally, the expression of miR21, miR27, and miR125, known as oncomirs, decreased significantly after xanthomicrol administration, while the expression of miR29 and miR34, functioning as tumor suppressors, increased significantly (p < .001) | |
| PubChem ID | 73207 | |
| Additional PMIDs | 34215226 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:458973-1 | |
| Safety | NA |