| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2117 | |
| Phytochemical name or plant extracts | Xanthinosin | |
| PMID | 26081757 | |
| Literature evidence | In search of bioactive natural products for overcoming TRAIL-resistance from natural resources, we previously reported a number of active compounds. | |
| IUPAC name | (3aR,7S,8aS)-7-methyl-3-methylidene-6-(3-oxobutyl)-4,7,8,8a-tetrahydro-3aH-cyclohepta[b]furan-2-one | |
| Phytochemicals’ class or type of plant extracts | Sesquiterpene lactone | |
| Source of phytochemicals or plant Extracts | Xanthium strumarium | |
| Geographical availability | Afghanistan, Albania, Algeria, Bulgaria, Cambodia, China North-Central, China South-Central, China Southeast, Corse, Czechoslovakia, East Aegean Is., East European Russia, East Himalaya, France, Greece, Hainan, Hungary, India, Inner Mongolia, Iran, Italy, Kriti, Krym, Laos, Lebanon-Syria, Manchuria, Mongolia, Morocco, Myanmar, North Caucasus, Pakistan, Palestine, Portugal, Qinghai, Romania, Sardegna, Sicilia, Sinai, South European Russi, Spain, Sri Lanka, Switzerland, Tadzhikistan, Taiwan, Thailand, Tibet, Transcaucasus, Turkey, Turkey-in-Europe, Turkmenistan, Ukraine, Uzbekistan, West Himalaya, Xinjiang, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Prostate cancer, Cervical cancer, Colorectal cancer | |
| Target gene or protein | DR4, DR5, p53, CHOP, Bax, Caspase 3, Caspase 8, Caspase 9, Bcl-2 | |
| Gene or Protein evidence | Compounds 1 and 5 enhanced the levels of apoptosis inducing proteins DR4, DR5, p53, CHOP, Bax, cleaved caspase-3, cleaved caspase-8, and cleaved caspase-9 and also decreased the levels of cell survival protein Bcl-2 in TRAIL-resistant AGS cells in a dose-dependent manner. Compound 1 also enhanced the levels of DR4 and DR5 proteins in a time-dependent manner. | |
| Target pathways | NA | |
| IC50 | 4.8±0.56 μg/mL against MDA-MB-231 | |
| Potency | Compound 1 also exhibit TRAIL-resistance overcoming activity in DLD1, DU145, HeLa, and MCF7 cells but did not decrease viability in non-cancer HEK293 cells up to 8 μM. | |
| Cell line/ mice model | DLD1, DU145, HeLa, MCF-7, MDA-MB-231 | |
| Additional information | NA | |
| PubChem ID | 44453629 | |
| Additional PMIDs | 18066118 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:260893-1 | |
| Safety | NA |