| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-416 | |
| Phytochemical name or plant extracts | Wogonoside | |
| PMID | 31696210 | |
| Literature evidence | Wogonoside, a bioactive flavonoid component derived from Scutellaria baicalensis Georgi, has been reported to inhibit tumor growth in mice bearing various types of cancer cells such as breast cancer, lung cancer, and leukemia cells. | |
| IUPAC name | (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(5-hydroxy-8-methoxy-4-oxo-2-phenylchromen-7-yl)oxyoxane-2-carboxylic acid | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Scutellaria baicalensis | |
| Geographical availability | Amur, Buryatiya, China North-Central, China South-Central, Chita, Inner Mongolia, Irkutsk, Khabarovsk, Korea, Manchuria, Mongolia, Primorye, Vietnam | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | MST1 | |
| Gene or Protein evidence | Mechanistically, wogonoside could aggravate the extent of ER stress and upregulate the phosphorylation level of Mammalian Ste20-like kinase 1, leading to the activation of the Hippo signaling pathway. | |
| Target pathways | Hippo signaling pathway | |
| IC50 | NA | |
| Potency | Taken together, in vitro and in vivo data demonstrated that wogonoside could be a potent inducer of ER stress and could be further developed into a promising therapy for endometrial cancer. | |
| Cell line/ mice model | TNBC cell xenograft model, HEC1A, BALB/c-nu mice | |
| Additional information | NA | |
| PubChem ID | 3084961 | |
| Additional PMIDs | 24026776 26852865 31178408 31696210 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:458155-1 | |
| Safety | NA |