| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1310 | |
| Phytochemical name or plant extracts | Wogonin | |
| PMID | 26578185 | |
| Literature evidence | Most free flavones (26-28 and 30) showed significant cytotoxic activities at 10 μM (up to 61.2% inhibition rate). | |
| IUPAC name | 5,7-dihydroxy-8-methoxy-2-phenylchromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Scutelleria baicalensis | |
| Geographical availability | Amur, Buryatiya, China North-Central, China South-Central, Chita, Inner Mongolia, Irkutsk, Khabarovsk, Korea, Manchuria, Mongolia, Primorye, Vietnam, Yakutskiya | |
| Plant parts | Root | |
| Other cancers | Breast cancer, Colon cancer, Liver cancer | |
| Target gene or protein | H2AX, Cyclin D1, p21, Cdc25A | |
| Gene or Protein evidence | The strongest anti-leukemic activity was shown by the methanol extract, which contained apigenin, baicalein, chrysin, luteolin and wogonin, with an IpC50 of 43 microg/ml which correlated with cyclin D1- and Cdc25A suppression and p21 induction. At 132 microg/ml this extract caused genotoxic stress indicated by substantial phosphorylation of the core histone H2AX. | |
| Target pathways | Blocks the PI3K/Akt/survivin signal pathways in MCF-7 cells Causes downregulation of the Akt-mediated canonical Wnt signaling pathway | |
| IC50 | At 48h, 72h: 92.12± 3.47 µM, 71.32± 2.74 µM against MCF-7 | |
| Potency | This study demonstrated that free flavones showed potent anti-influenza, anti-cancer and anti-oxidative activities. | |
| Cell line/ mice model | MCF-7, MDA?MB?231, MCF-7/DOX,SKBR-3, HepG2, SW480 and MCF-7 | |
| Additional information | Exhibits pro-apoptotic effect through the activation of ERK and the activation of caspases (MCF-7) Reverses drug resistance by down-regulating Nrf2-mediated cellular defense response (DOX resistant MCF-7: MCF-7/DOX cells) Inhibits the 5?LO/BLT2/ERK/IL?8/MMP?9 signaling cascade (MDA?MB?231 cells) Supresses the LPS?driven MDA?MB?231 cell metastasis (IN VIVO) Causes upregulation of PARP and Caspase 3 cleavages, and proapoptotic Bax protein, Supresse Akt activity and reduces phosphorylation of its substrates, GSK-3beta and p27, downregulates ER expression in ER-positive cells, and supresses c-ErbB2 expression and its activity in ER-negative SK-BR-3 cells | |
| PubChem ID | 5281703 | |
| Additional PMIDs | 19836937 22182776 22593043 30015917 17957784 19576743 30717533 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:458155-1 | |
| Safety | NA |