| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1573 | |
| Phytochemical name or plant extracts | White button mushroom | |
| PMID | 17178902 | |
| Literature evidence | Therefore, our studies illustrate the anticancer activity in vitro and in vivo of mushroom extract and its major fatty acid constituents. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethyl acetate fraction | |
| Source of phytochemicals or plant Extracts | Agaricus bisporous | |
| Geographical availability | France, United States | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bak-1 | |
| Gene or Protein evidence | Mushroom extract induces apoptosis in breast cancer cells by BAK-1 gene activation. | |
| Target pathways | Mushroom extract induces autophagy via the AMPK-mTOR signaling pathway in breast cancer cells | |
| IC50 | 40 µg/ml against MDA-MB-231 30 µg/ml against BT-20 | |
| Potency | The studies showed that mushroom extract decreased both tumor cell proliferation and tumor weight with no effect on rate of apoptosis. The association between higher mushroom consumption and lower risk of cancer, particularly breast cancer, may indicate a potential protective role for mushrooms in the diet. | |
| Cell line/ mice model | MCF-7, MCF-10A, MDA-MB-231, BT-20 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | 33724299 16391863 33798660 21480800 | |
| Additional sources of information | https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-023-09257-w | |
| Safety | Mushroom extract decreased testosterone-induced cell proliferation in MCF-7aro cells but had no effect on MCF-10A, a nontumorigenic cell line. |