| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1304 | |
| Phytochemical name or plant extracts | Wheatgrass extract | |
| PMID | 24691278 | |
| Literature evidence | Growth inhibitory and adjuvant therapeutic potential of aqueous extract of Triticum aestivum on MCF-7 and HeLa cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Aqueous extract | |
| Source of phytochemicals or plant Extracts | Triticum aestivum | |
| Geographical availability | India, Iran, Lebanon-Syria, Pakistan, Palestine, Transcaucasus, Turkey, West Himalaya | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Cervical cancer | |
| Target gene or protein | Bax, Cyclin D1 | |
| Gene or Protein evidence | AWE was found to induce apoptosis and arrested the cells at G0-G1 phase of the cell cycle which correlated with the modulation of expression of bax and cyclin D1 in a time-dependent manner in MCF-7 and HeLa cells. | |
| Target pathways | AWE treated cancer cells showed characteristic rounding off, cell shrinkage and detachment from the matrix, indicating that cell death induced by AWE is through apoptotic pathway | |
| IC50 | NA | |
| Potency | This study also provides the first evidence demonstrating synergism between AWE and cisplatin, which may enhance the therapeutic index of prevention and/or treatment of human breast and cervical cancer. | |
| Cell line/ mice model | MCF-7, HeLa | |
| Additional information | Lower dose combinations of AWE and cisplatin induced increased growth inhibition compared with the individual drugs on both cell lines (combination index < 1) indicating strong synergistic interactions. EC50 for MCF-7 cells was found to be 15% and 10% whereas for HeLa cells, it was found to be 25 and 15%, respectively, for 24 and 48 h. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:332110-2 | |
| Safety | NA |