| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1934 | |
| Phytochemical name or plant extracts | Vulpinic Acid | |
| PMID | 30179144 | |
| Literature evidence | CONCLUSION: It is implicated that VA may be a promising novel molecule for the induction of apoptosis on breast cancer cells. | |
| IUPAC name | methyl (2E)-2-(3-hydroxy-5-oxo-4-phenylfuran-2-ylidene)-2-phenylacetate | |
| Phytochemicals’ class or type of plant extracts | Depsidone | |
| Source of phytochemicals or plant Extracts | Candelaria concolor lichen | |
| Geographical availability | NA | |
| Plant parts | Lichen | |
| Other cancers | Breast cancer | |
| Target gene or protein | p53 | |
| Gene or Protein evidence | Results demonstrated that the gene expression of P53 genes was altered up to fourteen-fold levels in SK-BR-3 cell lines whereas it reached 2.5-fold in the MCF-12A cell line after treatment with VA. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | It is implicated that VA may be a promising novel molecule for the induction of apoptosis on breast cancer cells. | |
| Cell line/ mice model | MCF-7, SKBR-3 | |
| Additional information | hese observations support that VA induces apoptosis on the breast cancer cells compared with the non-cancerous human breast epithelial cell line. | |
| PubChem ID | 54690323 | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |