| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-377 | |
| Phytochemical name or plant extracts | Vitisin B | |
| PMID | 31497225 | |
| Literature evidence | Vitisin B as a novel fatty acid synthase inhibitor induces human breast cancer cells apoptosis. | |
| IUPAC name | [3-(4-hydroxy-3,5-dimethoxyphenyl)-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,8-dioxatricyclo[7.3.1.05,13]trideca-1(12),3,5(13),6,9-pentaen-11-ylidene]oxidanium | |
| Phytochemicals’ class or type of plant extracts | Stilbene | |
| Source of phytochemicals or plant Extracts | Iris lactea | |
| Geographical availability | Afghanistan, Altay, Buryatiya, China North-Central, China South-Central, China Southeast, Chita, Inner Mongolia, Irkutsk, Kazakhstan, Kirgizstan, Korea, Krasnoyarsk, Manchuria, Mongolia, Pakistan, Qinghai, Tadzhikistan, Tibet, Tuva, Uzbekistan, West Himalaya, Xinjiang | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer | |
| Target gene or protein | FAS | |
| Gene or Protein evidence | We found that vitisin B could down-regulate FAS expression and inhibit intracellular FAS activity in MDA-MB-231 cells. | |
| Target pathways | NA | |
| IC50 | 8.45 µg/ml against MDA-MB-231 | |
| Potency | Also, we reported for the first time that vitisin B exhibited apoptotic effect on human breast cancer cells. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | Given all of this, we proposed a hypothesis that vitisin B has an application potential in the chemoprevention and treatment of breast cancer. | |
| PubChem ID | 44195285 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:438774-1 | |
| Safety | NA |