| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-241 | |
| Phytochemical name or plant extracts | Vitexin | |
| PMID | 27630565 | |
| Literature evidence | Our data revealed that flax C-glucosides as well as pure compounds are cytotoxic toward MCF-7 cells and inhibit their proliferation. | |
| IUPAC name | 5,7-dihydroxy-2-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Oryza sativa | |
| Geographical availability | China North-Central, China South-Central, China Southeast | |
| Plant parts | Stem | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Caspase 7, Caspase 8, Caspase 9, p53, mdm2, Caspase 3 | |
| Gene or Protein evidence | Moreover, the induction of apoptosis was correlated with the changes in the mRNA level of pro-apoptotic genes. Increased expression of bax and caspase-7, -8, and -9 and decreased mRNA expression of bcl-2 was observed, whereas the mRNA levels of p53 and mdm2 were not altered. Our results showed significant up regulation of caspase 3 after exposure to vitexin 2-∆∆ct = 3.2 (P<0.001). Also we showed significant over expression of caspase 6, 8 in treated cells in comparison to non-treated cells 2-∆∆ct = 5.8 (P<0.001), 2∆-∆ct = 4.42 (P<0.0001) respectively. In conclusion, these data provided evidence for the apoptotic activity of vitexin, by a caspase dependent mechanism. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | The inhibition was stronger after 48 h of treatment and showed that vitexin reduced proliferation by up to 40% of the control value, while isoorientin inhibited proliferation by up to 50% , and orientin by up to 55% | |
| Cell line/ mice model | MCF-7 | |
| Additional information | These results clearly demonstrated that flax straw metabolites effectively induced growth inhibition and apoptosis in human breast adenocarcinoma cells. | |
| PubChem ID | NA | |
| Additional PMIDs | 14664747 27630565 27601844 21432719 20576412 30475503 34287803 21612369 31691589 27603115 37605736 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:316812-2 | |
| Safety | NA |