| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-930 | |
| Phytochemical name or plant extracts | Vitex rotundifolia extract | |
| PMID | 31160905 | |
| Literature evidence | Vitex rotundifolia fractions induce apoptosis in human breast cancer cell line, MCF-7, via extrinsic and intrinsic pathways. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | extract | |
| Source of phytochemicals or plant Extracts | Vitex rotundifolia | |
| Geographical availability | Borneo, China North-Central, China Southeast, Fiji, Hawaii, India, Japan, Jawa, Kazan-retto, Korea, Lesser Sunda Is., Malaya, Maluku, Manchuria, Nansei-shoto, New Caledonia, New Guinea, Northern Territory, Ogasawara-shoto, Philippines, Queensland, Samoa, Society Is., South China Sea, Sri Lanka, Sulawesi, Sumatera, Taiwan, Thailand, Vanuatu, Vietnam, Western Australia | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Bcl-2 , Caspase 3, Caspase 7, Caspase 9 | |
| Gene or Protein evidence | The V. rotundifolia fractions induced apoptosis by both pathways, extrinsic pathways via activation of caspase-8 and intrinsic pathways through enhanced bax/bcl-2 ratio and activation of caspase-3/7 and caspase-9 proapoptotic proteins. | |
| Target pathways | Extrinsic pathways via activation of caspase-8 and intrinsic pathways through enhanced bax/bcl-2 ratio and activation of caspase-3/7 and caspase-9 proapoptotic proteins | |
| IC50 | At 24h, 48h,72h: Extract - 63.09 ± 1.98 μg/mL at 72h against MCF-7 F1 - > 100 μg/mL, 44.66 ± 1.73 μg/mL, 29.51 ± 2.0 μg/mL against MCF-7 respectively F2 - > 100 μg/mL, 30.19 ± 3.73 μg/mL, 19.95 ± 2.68 μg/mL against MCF-7 respectively F3 - > 100 μg/mL, 15.84 ± 2.58 μg/mL, 6.30 ± 0.52 μg/mL against MCF-7 respectively F4 - > 100 μg/mL, 99.82 ± 0.14 μg/mL, 33.11 ± 3.60 μg/mL against MCF-7 respectively F5 - > 100 μg/mL, > 100 μg/mL, 26.30 ± 1.66 μg/mL against MCF-7 respectively F6 - > 100 μg/mL, > 100 μg/mL, > 100 μg/mL against MCF-7 respectively F7 - > 100 μg/mL, > 100 μg/mL, > 100 μg/mL against MCF-7 respectively | |
| Potency | The relative potential of cytotoxicity of the fractions on MCF-7 cell line was found to be F3 > F2 > F5 > F1. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | The phosphatidylserine externalization and the presence of DNA fragmentation in treated cells confirms the early and late apoptosis in treated cells. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:865973-1 | |
| Safety | NA |