| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-214 | |
| Phytochemical name or plant extracts | Viscum album (VA) extract | |
| PMID | 11933116 | |
| Literature evidence | The VA extract led to an improvement of DNA repair in gamma-ray or 4-HCy damaged PBMC and to a significant increase of the IFN-gamma-production both in undamaged and in damaged cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Viscum album | |
| Geographical availability | Albania, Algeria, Austria, Baleares, Baltic States, Belarus, Belgium, Bulgaria, Central European Rus, China South-Central, Corse, Czechoslovakia, Denmark, East European Russia, East Himalaya, France, Germany, Great Britain, Greece, Hungary, Iran, Italy, Kriti, Krym, Lebanon-Syria, Morocco, Myanmar, Nepal, Netherlands, North Caucasus, Northwest European R, Norway, Pakistan, Poland, Portugal, Romania, Sicilia, South European Russi, Spain, Sweden, Switzerland, Tibet, Transcaucasus, Turkey, Turkey-in-Europe, Ukraine, Vietnam, West Himalaya, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Pancreatic cancer, Lung cancer | |
| Target gene or protein | p21, p53, p73, p38, Erk1/2, H2A histone family member X | |
| Gene or Protein evidence | Causes down-regulation of p21, p53/p73 as well as Erk1/2 and p38 activation (in combination with Dox in MCF-7 cells) Mistletoe extract simultaneously increased the expression of the DNA damage marker proteins, phosphorylated H2A histone family member X (H2A.X), and phosphorylated p38. In addition to tumor growth inhibition, mistletoe extract inhibited lung metastasis in the tumor-bearing mice and cell invasiveness by downregulating the expressions of matrix metalloproteinases (MMPs), urokinase-type plasminogen activator (uPA), uPA receptor, and markers of epithelial-mesenchymal transition (snail and fibronectin). | |
| Target pathways | STAT3-FOXM1 Pathway | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | NCI-H460, DU-145, HCC1143, MV3, PA-TU-8902, SKBR-3, MCF-7, 4T1 tumor-bearing BALB/c mice | |
| Additional information | Inhibits VEGF secretion (In SK-BR-3 cells) and inhibits proliferation, causes both G0/G1 and G2/M arrest Increases the expression of the DNA damage marker proteins, phosphorylated H2A histone family member X (H2A.X), and phosphorylated p38 (in 4T1 murine breast cancer cells), downregulates the expressions of matrix metalloproteinases (MMPs), urokinase-type plasminogen activator (uPA), uPA receptor, and markers of epithelial-mesenchymal transition (snail and fibronectin) (4T1 tumor-bearing BALB/c mice) | |
| PubChem ID | NA | |
| Additional PMIDs | 9451423 7733629 12576206 11933116 15154645 16334172 16927530 16927532 17493268 17695469 3951791 2433654 24397864 27491866 28630419 30363769 30658716 33040629 32478590 1782081 33622211 34201348 11347286 24876872 23961426 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:300881-2 | |
| Safety | NA |