| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-170 | |
| Phytochemical name or plant extracts | Vernonia divaricata extract | |
| PMID | 25429469 | |
| Literature evidence | CONCLUSION: The medicinal use of V divaricata as an anti-cancer agent was corroborated as the crude hexane and methanol extracts demonstrated potent anti-proliferation activity and as such hold potential for further research and development into a drug to prevent or treat various cancers. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Vernonia divaricata | |
| Geographical availability | Costa Rica, Guatemala, Honduras, Mexico Central, Mexico Gulf, Mexico Northeast, Mexico Southeast, Mexico Southwest, Nicaragua, Panamá, Peru, Venezuelan Antilles, Windward Is. | |
| Plant parts | Leaves and stem | |
| Other cancers | Breast cancer, Leukemia, Prostate Cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 12.63 µg/ml against MCF-7 | |
| Potency | The medicinal use of V divaricata as an anti-cancer agent was corroborated as the crude hexane and methanol extracts demonstrated potent anti-proliferation activity and as such hold potential for further research and development into a drug to prevent or treat various cancers. | |
| Cell line/ mice model | HL-60, MCF-7, PC-3 | |
| Additional information | The crude hexane and methanol extracts of V divaricata were able to significantly retard the growth of the MCF-7 (breast), HL-60 (leukaemia) and the PC-3 (prostate) cancer cell lines. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:258246-1 | |
| Safety | NA |