| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-169 | |
| Phytochemical name or plant extracts | Vernonia amygdalina (VA) extract | |
| PMID | 24205071 | |
| Literature evidence | Overall, this study demonstrates the potential applications of VA as an anti-cancer drug for breast cancer treatment. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Vernonia amygdalina | |
| Geographical availability | Angola, Benin, Bolivia, Botswana, Brazil North, Brazil Northeast, Brazil Southeast, Brazil West-Central, Burkina, Cameroon, Central African Repu, Chad, Congo, Eritrea, Ethiopia, Gabon, Guinea, Gulf of Guinea Is., Ivory Coast, Kenya, KwaZulu-Natal, Liberia, Malawi, Mali, Mozambique, Namibia, Nigeria, Northern Provinces, Sierra Leone, Sudan, Swaziland, Tanzania, Togo, Yemen, Zambia, Zaïre, Zimbabwe | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | ERα, AKT | |
| Gene or Protein evidence | Given that approximately 70% of diagnosed breast cancers express ER-α, a crucial finding was that VA inhibits the expression of ER-α and its downstream player, Akt, highlighting the potential clinical significance of VA. | |
| Target pathways | Extrinsic and intrinsic apoptotic pathways | |
| IC50 | For 24h, 48h, 72h: 100 µg/mL, 66 µg/ml, 56 µg/ml against MCF-7 respectively 83 µg/mL, 53 µg/ml, 46 µg/ml against MDA-MB-231 respectively | |
| Potency | Overall, this study demonstrates the potential applications of VA as an anti-cancer drug for breast cancer treatment. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | The anti-cancer activities of Vernonia amygdalina extract in human breast cancer cell lines are mediated through caspase-dependent and p53-independent pathways Furthermore, this study revealed that VA induces apoptosis in the two cell lines, as indicated by the increase in Annexin V-positive cells and sub-G1 population, and that this VA-induced apoptosis occurred through both extrinsic and intrinsic apoptotic pathways. | |
| PubChem ID | NA | |
| Additional PMIDs | 12626774 19176872 27226742 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:257798-1 | |
| Safety | NA |