| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1880 | |
| Phytochemical name or plant extracts | Vernolepin | |
| PMID | 27311895 | |
| Literature evidence | In addition, 5 exhibited significant antiproliferative activities against HeLa and MDA-MB-231 cells, with IC50 values ranging from 1.90 to 2.20μM. | |
| IUPAC name | (1R,2S,6R,7S,9R)-9-ethenyl-7-hydroxy-1-methyl-5,13-dimethylidene-3,11-dioxatricyclo[7.4.0.0²,⁶]tridecane-4,12-dione | |
| Phytochemicals’ class or type of plant extracts | Sesquiterpene lactones | |
| Source of phytochemicals or plant Extracts | Vernonia anthelmintica | |
| Geographical availability | Afghanistan, Botswana, China South-Central, India, Kenya, Laos, Malawi, Mozambique, Myanmar, Namibia, Nepal, Pakistan, Sri Lanka, Tanzania, Uganda, Vietnam, West Himalaya, Zambia, Zaïre, Zimbabwe | |
| Plant parts | Seeds | |
| Other cancers | Cervical cancer, Breast cancer, Liver Cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 1.90 μM against MDA-MB-231 | |
| Potency | NA | |
| Cell line/ mice model | HeLa, MDA-MB-231, HepG2 | |
| Additional information | Induces apoptosis in HepG2 cells through G2/M phase cell cycle arrest | |
| PubChem ID | 442322 | |
| Additional PMIDs | 31445193 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:257826-1 | |
| Safety | NA |