| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-171 | |
| Phytochemical name or plant extracts | Vernolactone | |
| PMID | 30488799 | |
| Literature evidence | The present study was designed to isolate potential cytotoxic compound/s from chloroform and ethyl acetate extracts of V. zeylanica by bio-activity guided isolation and to evaluate its anti-proliferative effects in three breast cancer phenotypes (MCF -7, MDA-MB-231, SKBR-3). | |
| IUPAC name | (1S,2R,4R,7S,8E,11S,13R)-8-ethylidene-7-hydroxy-4,11-dimethyl-13-[2-(2-methyloxiran-2-yl)-2-oxoethyl]-15-[(prop-1-en-2-yloxy)methyl]-3,17-dioxatetracyclo[12.3.0.0²,⁴.0⁷,¹¹]heptadec-14-ene-9,16-dione | |
| Phytochemicals’ class or type of plant extracts | Sesquiterpene lactone | |
| Source of phytochemicals or plant Extracts | Vernonia zeylanica | |
| Geographical availability | Sri Lanka | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Survivin, p53, Bax, Caspase 3, Caspase 7 | |
| Gene or Protein evidence | Morphological changes, DNA fragmentation, increased caspase 3/7 activities and up-regulation of p53, Bax and down regulation of Survivin confirmed the proapoptotic effects of the compound. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MCF -7, MDA-MB-231, SKBR-3 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:259697-1 | |
| Safety | NA |