| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1878 | |
| Phytochemical name or plant extracts | Vernodalin | |
| PMID | 27311895 | |
| Literature evidence | In addition, 5 exhibited significant antiproliferative activities against HeLa and MDA-MB-231 cells, with IC50 values ranging from 1.90 to 2.20μM. | |
| IUPAC name | [(3aR,4S,5aR,9aR,9bR)-5a-ethenyl-3,9-dimethylidene-2,8-dioxo-3a,4,5,6,9a,9b-hexahydrofuro[2,3-f]isochromen-4-yl] 2-(hydroxymethyl)prop-2-enoate | |
| Phytochemicals’ class or type of plant extracts | Sesquiterpene lactone | |
| Source of phytochemicals or plant Extracts | Vernonia anthelmintica, Vernonia extensa, Centratherum anthelminticum | |
| Geographical availability | Vernonia anthelmintica - Afghanistan, Botswana, China South-Central, India, Kenya, Laos, Malawi, Mozambique, Myanmar, Namibia, Nepal, Pakistan, Sri Lanka, Tanzania, Uganda, Vietnam, West Himalaya, Zambia, Zaïre, Zimbabwe Vernonia extensa - Assam, Bangladesh, China South-Central, East Himalaya, Myanmar, Nepal, Thailand Centratherum anthelminticum - Afghanistan, Botswana, China South-Central, India, Kenya, Laos, Malawi, Mozambique, Myanmar, Namibia, Nepal, Pakistan, Sri Lanka, Tanzania, Uganda, Vietnam, West Himalaya, Zambia, Zaïre, Zimbabwe | |
| Plant parts | Seeds | |
| Other cancers | Lung cancer, Breast cancer, Cervical Cancer, Colon cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | Causes induction of apoptosis in human breast cancer cells via caspase pathway | |
| IC50 | 0.30 μM against MDA-MB-231 | |
| Potency | NA | |
| Cell line/ mice model | HepG2, MCF-7, MDA-MB-231, HeLa, A549 | |
| Additional information | Induces apoptosis in HepG2 cells through G2/M phase cell cycle arrest Causes increase in reactive oxygen species (ROS) production, downregulation of anti-apoptotic molecules (Bcl-2, Bcl-xL), which together leads to reduction of mitochondrial membrane potential (MMP) and release of cytochrome c (MCF-7 and MDA-MB-231) - triggering triggered activation of caspase cascade, PARP cleavage, DNA damage and eventually cell death Exhibits strong antiproliferative activities against three human cancer cell lines (A549, HeLa, and MDA-MB-231) | |
| PubChem ID | 179375 | |
| Additional PMIDs | 31445193 23437193 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:257826-1 https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:258336-1 https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:77131586-1 | |
| Safety | NA |