| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-673 | |
| Phytochemical name or plant extracts | Verbascoside | |
| PMID | 34844644 | |
| Literature evidence | BACKGROUND: Despite significant advancements in breast cancer therapy, novel drugs with lower side effects are still being demanded. | |
| IUPAC name | [(2R,3R,4R,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | |
| Phytochemicals’ class or type of plant extracts | Glycoside | |
| Source of phytochemicals or plant Extracts | Orobanche amethystea | |
| Geographical availability | Afghanistan, Albania, Algeria, Bulgaria, Canary Is., Corse, France, Germany, Great Britain, Greece, Iran, Italy, Kriti, Morocco, North Caucasus, Pakistan, Portugal, Sardegna, Sicilia, Spain, Switzerland, Tunisia, Turkey, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 3, Bax, Bcl-2, TLR4, MyD88, NF-κB | |
| Gene or Protein evidence | By qRT-PCR, we observed that verbascoside treatment (100, 117 and, 130 μM) increases the expression of caspase-3 and Bax while reduces the expression of Bcl-2. Also, verbascoside (100, 117 and, 130 μM) increased the expression of TLR4 only at 130 μM dose and the expression of MyD88 whereas reduced the expression of NF-κB at mRNA level. | |
| Target pathways | NA | |
| IC50 | 116.7 (~ 117) μM against 4 T1 0.127 μM against MCF-7 0.1597μM against MDA-MB-231 | |
| Potency | Flow cytometry analysis also confirmed verbascoside induces apoptosis in 4 T1 cells at 117 μM | |
| Cell line/ mice model | 4 T1, MCF-7, MDA-MB-231 | |
| Additional information | Taken together, our data showed verbascoside is a safe natural compound for normal cells while has apoptosis-inducing feature through TLR4 axis on 4 T1 cells | |
| PubChem ID | 5281800 | |
| Additional PMIDs | 18404597 34719192 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:662105-1 | |
| Safety | NA |