| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2169 | |
| Phytochemical name or plant extracts | Valtrate | |
| PMID | 30638055 | |
| Literature evidence | Valtrate from Valeriana jatamansi Jones induces apoptosis and inhibits migration of human breast cancer cells in vitro. | |
| IUPAC name | [(1S,6S,7R,7aS)-4-(acetyloxymethyl)-1-(3-methylbutanoyloxy)spiro[6,7a-dihydro-1H-cyclopenta[c]pyran-7,2'-oxirane]-6-yl] 3-methylbutanoate | |
| Phytochemicals’ class or type of plant extracts | Fatty acid ester | |
| Source of phytochemicals or plant Extracts | Valeriana jatamansi Jones | |
| Geographical availability | Afghanistan, Assam, China North-Central, China Southeast, East Himalaya, Myanmar, Nepal, Pakistan, Thailand, Tibet, Vietnam, West Himalaya | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | p-Akt, Cyclin B1, Caspase 8, p21, p-cdc2, Caspase 3, Caspase 9, MMP-9, MMP-2, PARP | |
| Gene or Protein evidence | Valtrate induced cell cycle arrest at G2/M stage and apoptosis in MDA-MB-231 and MCF-7 cells, with reduced expression of p-Akt (Ser 473), cyclin B1 and caspase 8, and increased expression of p21, p-cdc2, cleaved-caspase 3, cleaved-caspase 7 and poly (ADP-ribose) polymerase (PARP). In addition, valtrate inhibited cell migration through down-regulation of MMP-9 and MMP-2 expression. | |
| Target pathways | Akt signal pathway | |
| IC50 | 9.27 ± 1.91 μM against MCF-7 7.81 ± 1.39 μM against MDA-MB-231 8.20 ± 0.86 μM against MDA-MB-468 8.59 ± 1.64 μM against MDA-MB-453 30.55 ± 7.41 μM against MCF10A 17.73 ± 0.43 μM against SK-OV-3 | |
| Potency | hese results demonstrate that valtrate possesses anti-breast cancer activities via cell cycle arrest, apoptosis, and inhibition of cell migration, thus supporting valtrate as a potential antitumor agent. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, MDA-MB-468, MDA-MB-453, MCF10A, SK-OV-3 | |
| Additional information | The results of the present study indicate that valtrate not only inhibits proliferation, induces G2/M arrest and apoptosis, but also inhibits migration of human breast cancer cells. Moreover, Akt signal pathway may take part in valtrate-induced cell apoptosis. This study emphasizes the promising application of valtrate in breast cancer treatment. | |
| PubChem ID | 442436 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:60458931-2 | |
| Safety | Here, we found that valtrate exhibited significant anti-cancer activity in vitro, especially in human breast cancer cells, while displayed relatively low cytotoxicity to normal human breast epithelial cells (MCF 10A). |