| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1206 | |
| Phytochemical name or plant extracts | Valeriana officinalis extract | |
| PMID | 33510252 | |
| Literature evidence | This study highlights a potential utility of valeric acid as a novel HDAC inhibitor and a therapeutic agent in the treatment of breast cancer. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Aqueous extract | |
| Source of phytochemicals or plant Extracts | Valeriana officinalis | |
| Geographical availability | Albania, Austria, Baltic States, Belarus, Belgium, Bulgaria, Central European Rus, Corse, Czechoslovakia, Denmark, East European Russia, Finland, France, Germany, Great Britain, Greece, Hungary, Iran, Ireland, Italy, Krym, Netherlands, North Caucasus, North European Russi, Northwest European R, Norway, Poland, Portugal, Romania, Sardegna, South European Russi, Spain, Sweden, Switzerland, Transcaucasus, Turkey, Turkey-in-Europe, Ukraine, Yugoslavia | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Our results showed that aqueous valerian extract reduced growth of breast cancer cells.We have shown that valerian root and valeric acid (a major compound of valerian root) can inhibit proliferation, migration, colony formation and 3D formation of breast cancer cells in a dose- and time-dependent manner. | |
| Cell line/ mice model | MDA-MB-231, MCF-7, MCF-10A | |
| Additional information | Valerian has been approved as a Generally Recognized as Safe (GRAS) food ingredient by the U.S. Food and Drug Administration (FDA). | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:860012-1 | |
| Safety | NA |