| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1969 | |
| Phytochemical name or plant extracts | Usnic Acid | |
| PMID | 33099129 | |
| Literature evidence | Among the compounds isolated, usnic acid exhibited moderately potent antiproliferative activities against the A2780 ovarian (IC50 3.8 μM) and MCF-7 breast cancer (IC50 6.8 μM) cell lines. | |
| IUPAC name | 2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzofuran-1,3-dione | |
| Phytochemicals’ class or type of plant extracts | Benzofuran | |
| Source of phytochemicals or plant Extracts | Niebla homalea | |
| Geographical availability | United States | |
| Plant parts | Lichen | |
| Other cancers | Breast cancer, Cervical cancer, Liver cancer, Ovarian cancer, Leukemia | |
| Target gene or protein | hsa-miR-5006-5p, hsa-miR-892c-3p, hsa-miR-4430, hsa-miR-5194, hsa-miR-3198, hsa-miR-3171, hsa-miR-933, hsa-miR-185-3p | |
| Gene or Protein evidence | We found that usnic acid treatment caused significant changes in the expression of hsa-miR-5006-5p, hsa-miR-892c-3p, hsa-miR-4430, hsa-miR-5194, hsa-miR-3198, hsa-miR-3171, hsa-miR-933 and hsa-miR-185-3p in breast cancer cells. | |
| Target pathways | NA | |
| IC50 | 6.8 μM against MCF-7 | |
| Potency | Atranorin and fumarprotocetraric acid did not exhibit anti-proliferative effects but usnic acid was active against all test cell lines with EC50 values of 4.3-8.2 microg/ml. | |
| Cell line/ mice model | A2780, HeLa, MCF-7, SKBR-3, HT-29, HCT-116 p53(+/+), HCT-116 p53(-/-), HL-60 and Jurkat | |
| Additional information | Our study reports on the sensitivity of up to nine human cancer cell lines (A2780, HeLa, MCF-7, SK-BR-3, HT-29, HCT-116 p53(+/+), HCT-116 p53(-/-), HL-60 and Jurkat) to the anti-proliferative/cytotoxic effects of four typical secondary metabolites of lichens (parietin, atranorin, usnic acid and gyrophoric acid). | |
| PubChem ID | 5646 | |
| Additional PMIDs | 31282672 31549595 33099129 15784343 20837130 | |
| Additional sources of information | NA | |
| Safety | NA |