| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1358 | |
| Phytochemical name or plant extracts | Urtica dioica extract | |
| PMID | 26950453 | |
| Literature evidence | Nuclei Staining in TUNEL and DNA fragments in DNA fragmentation assay and increase in the mRNA expression levels of caspase-3, caspase-9, decrease in the bcl2 and no significant change in the caspase-8 mRNA expression level, showed that the induction of apoptosis was the main mechanism of cell death that induce by Urtica dioica extract. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Dichloromethane extract, Aqueous extract | |
| Source of phytochemicals or plant Extracts | Urtica dioica | |
| Geographical availability | Afghanistan, Albania, Algeria, Altay, Amur, Assam, Austria, Baltic States, Belarus, Belgium, Bulgaria, Buryatiya, Central European Rus, China North-Central, China South-Central, Chita, Corse, Czechoslovakia, Denmark, East Aegean Is., East European Russia, East Himalaya, Finland, France, Føroyar, Germany, Great Britain, Greece, Hungary, Iceland, India, Inner Mongolia, Iran, Iraq, Ireland, Irkutsk, Italy, Japan, Kamchatka, Kazakhstan, Khabarovsk, Kirgizstan, Korea, Krasnoyarsk, Kriti, Krym, Lebanon-Syria, Magadan, Manchuria, Mongolia, Morocco, Nepal, Netherlands, North Caucasus, North European Russi, Northwest European R, Norway, Pakistan, Poland, Portugal, Primorye, Qinghai, Romania, Sakhalin, Sardegna, Sicilia, South European Russi, Spain, Sweden, Switzerland, Tadzhikistan, Tibet, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Turkmenistan, Tuva, Ukraine, Uzbekistan, West Himalaya, West Siberia, Xinjiang, Yakutskiya, Yugoslavia | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | miR-21, Caspase 3, Caspase 9, Bcl-2, MMP1, MMP9, MMP13, Vimentin, CXCR4, E-Cadherin, ODC1, ADA | |
| Gene or Protein evidence | Urtica dioica extract suppresses miR-21 and metastasis-related genes in breast cancer. These results demonstrated that Urtica dioica induces apoptosis in breast cancer cells by influencing ODC1 and ADA genes expression, and estrogen receptors. Urtica dioica extract could inhibit cancer cell migration by regulating miR-21, MMP1, MMP9, MMP13, vimentin, CXCR4, and E-Cadherin. Nuclei Staining in TUNEL and DNA fragments in DNA fragmentation assay and increase in the mRNA expression levels of caspase-3, caspase-9, decrease in the bcl2 and no significant change in the caspase-8 mRNA expression level, showed that the induction of apoptosis was the main mechanism of cell death that induce by Urtica dioica extract. | |
| Target pathways | NA | |
| IC50 | 2 mg/ml against MCF-7 for 72h | |
| Potency | NA | |
| Cell line/ mice model | MDA-MB-468, MCF - 7 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | 24175819 27501501 28980930 31163183 26950453 28501502 28628833 29506637 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:260630-2 | |
| Safety | NA |