| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1703 | |
| Phytochemical name or plant extracts | Unguinol | |
| PMID | 31788435 | |
| Literature evidence | This study, therefore, investigated the potential of two depsidones (Unguinol and Aspergillusidone D) to induce apoptosis, cell cycle arrest and cytotoxicity, and reduce cell proliferation in the triple-negative MDA-MB-231 breast cancer cell line. | |
| IUPAC name | 1-[(E)-but-2-en-2-yl]-3,9-dihydroxy-4,7-dimethylbenzo[b][1,4]benzodioxepin-6-one | |
| Phytochemicals’ class or type of plant extracts | Depsidones | |
| Source of phytochemicals or plant Extracts | Aspergillus | |
| Geographical availability | NA | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Aromatase | |
| Gene or Protein evidence | Naturally occurring depsidones, extracted from the fungus Aspergillus, are known for their wide range of biological activities such as cytotoxicity, aromatase inhibition, radical scavenging, and antioxidant properties. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Our research shows the potential of two depsidones to reduce triple-negative breast cancer cell survival. Therefore, this group of compounds may be promising in the search for new cancer treatments | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | NA | |
| PubChem ID | 14131420 | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |