| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1202 | |
| Phytochemical name or plant extracts | Uncaria rhynchophylla (UPAs) | |
| PMID | 28689063 | |
| Literature evidence | Altogether, these data suggest that UPAs are potential therapeutic agents for breast cancer. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Uncaria rhynchophylla | |
| Geographical availability | China South-Central, China Southeast, Japan, Taiwan, Vietnam | |
| Plant parts | Medicinal parts | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Bcl-2 , Caspase 3 | |
| Gene or Protein evidence | Moreover, UPAs induced apoptosis in a dose-dependent manner which was associated with increased cellular reactive oxygen species production, loss of mitochondrial membrane potential, increases of Bax/Bcl-2 ratio and levels of cleaved caspase 3. | |
| Target pathways | High concentrations of UPAs induced cell death/apoptosis associated with ROS generation and intrinsic apoptotic signaling pathway meanwhile sub-lethal UPAs doses inhibited the migration ability of MDA-MB-231 cells. | |
| IC50 | NA | |
| Potency | Altogether, these data suggest that UPAs are potential therapeutic agents for breast cancer. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | UPAs as therapeutic agents for breast cancer treatment, also substantiating the potential of UPAs and 5-FU combination therapy as a novel anti-breast cancer strategy. | |
| PubChem ID | NA | |
| Additional PMIDs | 28689063 29373834 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:768297-1 | |
| Safety | NA |