| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-902 | |
| Phytochemical name or plant extracts | Umbelliprenin | |
| PMID | 17689942 | |
| Literature evidence | The finding that the cytotoxic effect of umbelliprenin is markedly more pronounced in M4Beu cells than in primary fibroblasts, suggests a therapeutic margin. | |
| IUPAC name | 7-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoxy]chromen-2-one | |
| Phytochemicals’ class or type of plant extracts | Coumarin | |
| Source of phytochemicals or plant Extracts | Ferula szowitsiana | |
| Geographical availability | Afghanistan, Iran, Transcaucasus, Turkey, Turkmenistan, Uzbekistan | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Lung cancer, Prostate cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | We have observed that the cell susceptibility to umbelliprenin decreases in the order M4Beu (metastatic pigmented malignant melanoma)>A549 (nonsmall cell lung carcinoma) approximately PC3 (androgen-resistant prostate carcinoma)>PA1 (ovary teratocarcinoma)>human primary fibroblasts approximately MCF7 (breast adenocarcinoma)>DLD1 (colon adenocarcinoma). | |
| Cell line/ mice model | MCF-7, M4Beu, A549, PC3, PA1 | |
| Additional information | NA | |
| PubChem ID | 1781413 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:842521-1 | |
| Safety | NA |