| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-109 | |
| Phytochemical name or plant extracts | Ugonin J | |
| PMID | 23662114 | |
| Literature evidence | Among these flavonoids, ugonins J and K were found to be able to induce apoptosis in non-CSC populations and to reduce self-renewal growth of CD24(-/low)CD44(+) CSC population. | |
| IUPAC name | L (9-11), 5,4'-dihydroxy-4'',4''-dimethyl-5''-methyl-5''H-dihydrofurano[2'',3'':6,7]flavanone | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Helminthostachys zeylanica | |
| Geographical availability | Assam, Bangladesh, Bismarck Archipelago, Borneo, Cambodia, Caroline Is., China South-Central, China Southeast, East Himalaya, Hainan, India, Laos, Lesser Sunda Is., Malaya, Maluku, Marianas, Myanmar, Nansei-shoto, Nepal, New Caledonia, New Guinea, Nicobar Is., Northern Territory, Philippines, Queensland, Santa Cruz Is., Solomon Is., Sri Lanka, Sulawesi, Sumatera, Taiwan, Thailand, Vanuatu, Vietnam, West Himalaya, Western Australia | |
| Plant parts | Rhizome | |
| Other cancers | Breast cancer | |
| Target gene or protein | p53, NANOG | |
| Gene or Protein evidence | This suppression was possibly due to p53 activation and NANOG reduction as either addition of p53 inhibitor or overexpression of NANOG can counteract the suppressive effect of ugonin J. | |
| Target pathways | NA | |
| IC50 | < 25 μM against MCF-7, MDA-MB231 | |
| Potency | Treatment with ugonin J significantly reduced the tumorigenicity of MCF-7 cells and efficiently suppressed formation of mammospheres. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | NA | |
| PubChem ID | 12114697 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:17116690-1 | |
| Safety | NA |