| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-942 | |
| Phytochemical name or plant extracts | Typhonium flagelliforme tuber extract | |
| PMID | 33342788 | |
| Literature evidence | Typhonium flagelliforme extract induce apoptosis in breast cancer stem cells by suppressing survivin. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Typhonium flagelliforme | |
| Geographical availability | Andaman Is., Assam, Bangladesh, Cambodia, China South-Central, China Southeast, India, Jawa, Lesser Sunda Is., Malaya, Myanmar, New Guinea, Northern Territory, Philippines, Queensland, Sri Lanka, Thailand, Vietnam, West Himalaya | |
| Plant parts | Tuber | |
| Other cancers | Breast cancer | |
| Target gene or protein | Survivin, Caspase 9, Caspase 3 | |
| Gene or Protein evidence | TFTe also significantly decreased the expression levels of survivin in bCSCs (P < 0.001) and increased the expression levels of caspase-9 and caspase-3 (P < 0.001) | |
| Target pathways | NA | |
| IC50 | TFTe inhibited bCSC proliferation, with an IC50 value of 50.89 μg/mL, and significantly induced apoptosis in bCSCs (P < 0.001). | |
| Potency | TFTe can induce apoptosis in bCSCs by decreasing survivin expression levels and increasing the levels of caspase-9 and caspase-3. | |
| Cell line/ mice model | Breast cancer stem cells (bCSCs) | |
| Additional information | Typhonium flagelliforme tuber extract (TFTe) can induce apoptosis in several types of cancer cells | |
| PubChem ID | NA | |
| Additional PMIDs | 19833183 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:89233-1 | |
| Safety | NA |