| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2065 | |
| Phytochemical name or plant extracts | Tubeimoside-1 | |
| PMID | 30315250 | |
| Literature evidence | To gain a better understanding of how traditional Chinese medicine agents exert antitumor effects, we screened 480 natural compounds for their effects on autophagy using a high content screening assay detecting GFP-LC3 puncta in HeLa cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid saponin | |
| Source of phytochemicals or plant Extracts | Bolbostemma paniculatum | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Inner Mongolia | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Mcl-1, Bcl-xL, Bcl-2 | |
| Gene or Protein evidence | In three human breast cancer cell lines, we demonstrated that Akt-mTOR-eEF-2K pathway was involved in TBMS1-induced activation of autophagy, while Akt-mediated downregulations of Mcl-1, Bcl-xl, and Bcl-2 led to the activation of apoptosis of the breast cancer cells. | |
| Target pathways | Akt-mTOR-eEF-2K pathway | |
| IC50 | NA | |
| Potency | Our results demonstrate the role and mechanism of TBMS1 in activating autophagy, suggesting that inhibition of cytoprotective autophagy may act as a therapeutic strategy to reinforce the activity of TBMS1 against cancers. | |
| Cell line/ mice model | MDA-MB-231, T47D | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:291523-1 | |
| Safety | NA |