| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-739 | |
| Phytochemical name or plant extracts | Trollius chinensis flavonoids | |
| PMID | 27602105 | |
| Literature evidence | Taken together, the results confirmed the ability of T. chinensis flavonoids to inhibit cell proliferation. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Trollius chinensis | |
| Geographical availability | Amur, Buryatiya, China North-Central, China Southeast, Chita, Inner Mongolia, Khabarovsk, Korea, Krasnoyarsk, Kuril Is., Manchuria, Mongolia, Primorye, Sakhalin | |
| Plant parts | Flowers | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2, NF-κB, Caspase 9, Caspase 3 | |
| Gene or Protein evidence | Cells treated with T. chinensis flavonoids selectively reduced bcl-2 and NF-κB expression and increased the expression of caspase-9 and caspase-3 indicating that the inhibition of cellular proliferation occurred through activation of a mitochondrial pathway. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Taken together, the results confirmed the ability of T. chinensis flavonoids to inhibit cell proliferation. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | There is no change in FasL and p53 protein expression, so the FasL and p53 protein could not lead to the apoptosis of EC-109 cells. Therefore, T. chinensis flavonoids may have the potential to be developed as a novel anti-breast cancer drug. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:715085-1 | |
| Safety | NA |