| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1442 | |
| Phytochemical name or plant extracts | Triptoquinone A | |
| PMID | 29258353 | |
| Literature evidence | All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Compounds 1-7 showed significant inhibitory effects against various human cancer cell lines with IC50 values ranging from 0.58 to 21.06 ?M. | |
| IUPAC name | (4aS,10aS)-1,4a-dimethyl-5,8-dioxo-7-propan-2-yl-4,9,10,10a-tetrahydro-3H-phenanthrene-2-carboxylic acid | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Tripterygium regelii | |
| Geographical availability | Japan, Korea, Manchuria | |
| Plant parts | Root | |
| Other cancers | Breast cancer, Leukemia, Liver cancer, Lung cancer, Colorectal cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 9.72 ± 0.14 µM against MCF-7 | |
| Potency | NA | |
| Cell line/ mice model | HL-60, SMMC-7721, A-549, MCF-7, SW480 | |
| Additional information | NA | |
| PubChem ID | 132524 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:162907-1 | |
| Safety | NA |