| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-83 | |
| Phytochemical name or plant extracts | Triptonide | |
| PMID | 33510281 | |
| Literature evidence | These results indicate that triptonide holds promise as a novel anti-tumor agent for TNBC treatment. | |
| IUPAC name | (1S,2S,4S,5S,7S,9S,11S,13S)-1-methyl-7-propan-2-yl-3,6,10,16-tetraoxaheptacyclo[11.7.0.02,4.02,9.05,7.09,11.014,18]icos-14(18)-ene-8,17-dione | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Tripterygium wilfordii | |
| Geographical availability | China South-Central, China Southeast, Myanmar, Taiwan, Tibet, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | SNAI1 | |
| Gene or Protein evidence | We show that triptonide downregulates multiple cancer stem cell-associated genes but upregulates SNAI1 gene expression. In support of SNAI1 induction as a negative feedback response to triptonide treatment, in vitro-derived triptonide-resistant HCC1806 cells display a markedly higher expression of SNAI1 compared with parental cells. | |
| Target pathways | JNK signaling | |
| IC50 | NA | |
| Potency | These results indicate that triptonide holds promise as a novel anti-tumor agent for TNBC treatment | |
| Cell line/ mice model | HCC1806, BT-549, MDA-MB-231 | |
| Additional information | Our study also reveals a SNAI1-associated feedback mechanism which may lead to acquired resistance to triptonide. | |
| PubChem ID | 65411 | |
| Additional PMIDs | 1842005 33510281 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:162908-1 | |
| Safety | NA |