| Properties | Information |
|---|---|
| PhytoCAT-ID | PhytoCAT-1582 |
| Phytochemical name or plant extracts | Triphala |
| PMID | 17998642 |
| Literature evidence | Investigations in our laboratory have focused on the mechanism of activity of variety of anticancer and antioxidant agents, namely, Eugenol, (EU), Ellagic acid (EA), Triphala (TPL), Tocopherol Succinate (TOS) and Arachidonic acid on normal and cancer cells with view to design effective protocols in practical radioprotection and cancer radiotherapy. |
| IUPAC name | NA |
| Phytochemicals’ class or type of plant extracts | Triphala (Trl) is an ayurvedic formulation |
| Source of phytochemicals or plant Extracts | NA |
| Geographical availability | NA |
| Plant parts | NA |
| Other cancers | Breast cancer, Cervical cancer |
| Target gene or protein | p53 |
| Gene or Protein evidence | Present results have demonstrated that MCF 7 and T 47 D cells exhibited differential sensitivity to TPL, which seems to be dependant on their p53 status. Inhibition of anti-proliferative ability of TPL by antioxidants suggests a role for TPL induced ROS in the induction of apoptosis. It is concluded that p53 status of cancer cells formed an important factor in predicting the response of cancer cells to prooxidant drugs. |
| Target pathways | NA |
| IC50 | At 72h: 8 µg/ml against MCF-7 26 µg/ml against T47D |
| Potency | Trl inhibited proliferation of HeLa (cervical adenocarcinoma), PANC-1 (pancreatic adenocarcinoma), and MDA-MB-231 (triple-negative breast carcinoma) cells in microgram quantities and strongly suppressed the clonogenicity of HeLa cells. |
| Cell line/ mice model | HeLa, MCF-7, T47D, MD-MB-231 |
| Additional information | Triphala (Trl) is an ayurvedic formulation used for treating disorders of the digestive, respiratory, and nervous systems. Exogenous addition of antioxidants, glutathione (GSH) and N-Acetyl-Cysteine (NAC) inhibited the anti-proliferative ability of TPL in both MCF 7 and T47 D. Cells treated with Trl eventually underwent programmed cell death as evidenced by annexin-V staining. Our study shows that the effect of aqueous extract of Trl is potent enough to interfere with the assembly dynamics of microtubules, and that Trl can be investigated further for its antitumor potential. |
| PubChem ID | NA |
| Additional PMIDs | 29245069 16135398 |
| Additional sources of information | NA |
| Safety | NA |