| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1574 | |
| Phytochemical name or plant extracts | Tricin | |
| PMID | 17256728 | |
| Literature evidence | P-glycoprotein inhibitory activity of two phenolic compounds, (-)-syringaresinol and tricin from Sasa borealis. | |
| IUPAC name | 5,7-dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)chromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Sasa borealis | |
| Geographical availability | Japan, Korea, Sakhalin | |
| Plant parts | Whole plant | |
| Other cancers | Breast cancer, Colon cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 0.6 µM against MDA-MB-468 | |
| Potency | Tricin was the most potent anticlonogenic of the compounds with IC50s of 16 microM in the SW 480 colon cells and 0.6 microM in the MDA MB 468 breast cells. | |
| Cell line/ mice model | MDA MB 468, MCF-7, SW480 | |
| Additional information | Flavonoids are also SULT inhibitors, tricin is a competitive inhibitor of SULT 1E1 with a K(i) of 1.5+/-0.8 nM. Four new apigenin derivatives, 7-de-O-methylaciculatin, 8-C-β-D-boivinopyranosylapigenin, aciculatinone, and 4'-O-glucosylaciculatin, along with eight known compounds, apigenin-8-carbaldehyde, kaempferol, tricin, taxifolin, 6,7,4'-trihydroxyflavone, trans-oxyresveratrol, aciculatin, and luteolin-7-sulfate, were isolated from an ethanolic extract of Chrysopogon aciculatis. (-)-Syringaresinol and tricin, isolated from the AcOEt-soluble extract of the whole plants of Sasa borealis (Gramineae), showed inhibitory effects on the P-glycoprotein in adriamycin-resistant human breast cancer cells, MCF-7/ADR. | |
| PubChem ID | 5281702 | |
| Additional PMIDs | 17256728 30271444 11097223 22272829 17933522 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:420715-1 | |
| Safety | NA |