| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1852 | |
| Phytochemical name or plant extracts | Trichothecinol A | |
| PMID | 25633363 | |
| Literature evidence | Trichothecinol A (10) significantly inhibited the growth of MCF-7 cells, with an IC50 value of 0.006 µM, which was comparable to the cytotoxic activity of the positive control, paclitaxel, indicating that trichothecinol A (10) represents a potential anticancer agent. | |
| IUPAC name | [(1S,2R,7R,9R,10R,11S,12S)-10-hydroxy-1,2,5-trimethyl-4-oxospiro[8-oxatricyclo[7.2.1.02,7]dodec-5-ene-12,2'-oxirane]-11-yl] (Z)-but-2-enoate | |
| Phytochemicals’ class or type of plant extracts | Sesquiterpenoid | |
| Source of phytochemicals or plant Extracts | Engleromyces goetzii | |
| Geographical availability | NA | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 0.006 µM against MCF-7 | |
| Potency | Trichothecinol A (10) represents a potential anticancer agent. | |
| Cell line/ mice model | HL-60, SMMC-7721, A549, MCF-7, SW-480 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |