| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1200 | |
| Phytochemical name or plant extracts | Trichosanthes kirilowii extract | |
| PMID | 24194785 | |
| Literature evidence | In the present study, we tested whether Trichosanthes kirilowii ethanol extract (TKE) or CuD suppresses cell growth and induces apoptosis through inhibition of STAT3 activity in breast cancer cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Trichosanthes kirilowli | |
| Geographical availability | Cambodia, China North-Central, China Southeast, Inner Mongolia, Japan, Korea, Laos, Nansei-shoto, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | STAT-3 | |
| Gene or Protein evidence | In addition, both TKE and CuD inhibited nuclear translocation and transcriptional activity of STAT3. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Our results indicate that TKE and its derived compound, CuD, could be potent therapeutic agents for breast cancer, blocking tumor cell proliferation and inducing apoptosis through suppression of STAT3 activity. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | Moreover, exposure to TKE and CuD resulted in an increase in G2/M phase cells, accompanied by a decrease in G1 phase cells in MDA-MB-231 cells | |
| PubChem ID | NA | |
| Additional PMIDs | 22957017 24194785 32878798 32957363 | |
| Additional sources of information | https://pfaf.org/user/Plant.aspx?LatinName=Trichosanthes+kirilowii | |
| Safety | NA |