| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-568 | |
| Phytochemical name or plant extracts | Tricetin | |
| PMID | 19705844 | |
| Literature evidence | These findings suggest that tricetin may be a promising chemopreventive agent against human breast cancer. | |
| IUPAC name | 5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Punica granatum | |
| Geographical availability | Afghanistan, Iran, Iraq, North Caucasus, Pakistan, Tadzhikistan, Transcaucasus, Turkey, Turkmenistan | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Bak, p21, cdc2, cdc25C, Cyclin B, Bcl-2, Bcl-xL, ABCG2 | |
| Gene or Protein evidence | Tricetin can inhibit cell cycle progression at the G2/M phase by increasing p21 expression in a p53-dependent manner, and by decreasing the expression of cdc2, cdc25C, and cyclin B. tricetin treatment resulted in a significant increase of Bax and Bak expression, and a decrease of Bcl-2 and Bcl-XL, suggesting that changes in the ratio of the proapoptotic and antiapoptotic Bcl-2 family proteins might contribute to the apoptosis-promotion activity of tricetin. Chrysoeriol, laricitrin, myricetin 3',4',5'-trimethylether, pinocembrin, quercitrin, tamarixetin, tricetin and tricetin 3',4',5'-trimethylether were also identified as novel flavonoid ABCG2 inhibitors. | |
| Target pathways | NA | |
| IC50 | 32.17 μM against MCF-7 cells | |
| Potency | These findings suggest that tricetin may be a promising chemopreventive agent against human breast cancer. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | In addition, pretreatment of cells with caspase-9 inhibitor blocked tricetin-induced apoptosis, indicating that caspase-9 activation is involved in tricetin-mediated MCF-7 cell apoptosis. | |
| PubChem ID | 5281701 | |
| Additional PMIDs | 23497885 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:554129-1 | |
| Safety | NA |