| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-986 | |
| Phytochemical name or plant extracts | Trans-isoshinanolone | |
| PMID | 28933383 | |
| Literature evidence | As part of our search for natural products having antioxidant and anticancer properties, the phytochemical investigation of Diospyros shimbaensis (Ebenaceae), a plant belonging to a genus widely used in East African traditional medicine, was carried out. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Tetralones | |
| Source of phytochemicals or plant Extracts | Diospyros shimbaensis | |
| Geographical availability | Kenya, Tanzania | |
| Plant parts | Stem and Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | >520 μM against MDA-MB-231 | |
| Potency | EC50 = >25µM | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | Compounds 2, 4, and 5 were therefore assayed for activity against the MDA-MB-231 ER negative breast cancer cell line. Compounds 1 and 3 were only obtained in minute quantities and could therefore unfortunately not be assayed. Whereas 2 showed low toxicity, compounds 4 and 5 were active against the MDA-MB-231 cancer cells. Compound 2 is trans-isoshinanolone | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:935986-1 | |
| Safety | NA |