| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-733 | |
| Phytochemical name or plant extracts | Trans-epsilon-viniferin | |
| PMID | 12135100 | |
| Literature evidence | Six stilbenes showed cytotoxic activity in a dose-dependent manner, and especially did potent cytotoxic activity against C6 (mouse glioma) cancer cell with IC50 values ranging from 8.2 to 20.5 microg/ml. trans-Resveratrol showed significant cytotoxic activity against HepG2 (liver hepatoma) and HT-29 (colon) human cancer cell lines with IC50 values of 11.8 and 25.2 g/ml, respectively. | |
| IUPAC name | 5-[(2S,3S)-6-hydroxy-2-(4-hydroxyphenyl)-4-[(E)-2-(4-hydroxyphenyl)ethenyl]-2,3-dihydro-1-benzofuran-3-yl]benzene-1,3-diol | |
| Phytochemicals’ class or type of plant extracts | Stilbenoid | |
| Source of phytochemicals or plant Extracts | Paeonia lactiflora | |
| Geographical availability | Amur, China North-Central, China South-Central, China Southeast, Chita, Inner Mongolia, Khabarovsk, Manchuria, Mongolia, Primorye | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer, Cervical cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 44.8 μg/ml against MCF-7 | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, Hela, , HT-29, HePG2 | |
| Additional information | Trans-ε-viniferin (TV) was identified as a TMEM16A inhibitor with inhibitory activity against TMEM16A mediated Cl- currents, which was reversible, without affecting intracytoplasmic Ca2+ concentration and TMEM16A protein expression. | |
| PubChem ID | 5315233 | |
| Additional PMIDs | 36625145 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:711802-1 | |
| Safety | NA |