| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1988 | |
| Phytochemical name or plant extracts | Trans-anethole (TA) | |
| PMID | 34000264 | |
| Literature evidence | Network pharmacology-based evaluation of natural compounds with paclitaxel for the treatment of metastatic breast cancer. | |
| IUPAC name | 1-methoxy-4-[(E)-prop-1-enyl]benzene | |
| Phytochemicals’ class or type of plant extracts | Monomethoxybenzene | |
| Source of phytochemicals or plant Extracts | Foeniculum vulgare | |
| Geographical availability | Afghanistan, Albania, Algeria, Baleares, Bulgaria, Corse, Cyprus, East Aegean Is., Egypt, Eritrea, Ethiopia, France, Greece, Gulf States, Iran, Iraq, Italy, Kriti, Lebanon-Syria, Libya, Morocco, Nepal, North Caucasus, Pakistan, Palestine, Portugal, Sardegna, Saudi Arabia, Sicilia, Sinai, Spain, Tadzhikistan, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Turkmenistan, Uzbekistan, West Himalaya, Yemen, Yugoslavia | |
| Plant parts | Seeds and Aerial parts | |
| Other cancers | Breast cancer, Leukemia | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | The cytotoxicity of F. vulgare oil is most likely due to the lipophilic properties of essential oil and alkylating properties of the major components trans-anethole and p-anisaldehyde. | |
| Cell line/ mice model | NA | |
| Additional information | In addition, trans-anethole, the main component of the essential oil, was examined for its cytotoxicity in RC-37 cells. Its IC50 value was 100 mg L−1. CAM assay results suggested that AND, SIL and TA increase the anti-angiogenic potential of (Paclitaxel) PTX. Thus, natural compounds can be used to improve the anti-cancer potential of PTX. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |