| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1769 | |
| Phytochemical name or plant extracts | Toxicarioside M | |
| PMID | 22348979 | |
| Literature evidence | The cardenolides were evaluated for their cytotoxic activity against KB, HCT-116, SF-268, MCF-7, HL-60, PC-3 and MRC-5 cell lines. | |
| IUPAC name | 4-[(1R,3aS,5aS,7S,9aS,11aR)-3a,5a,9a-trihydroxy-11a-methyl-7-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]-2,5-dihydrofuran-2-one | |
| Phytochemicals’ class or type of plant extracts | Monoterpenoid | |
| Source of phytochemicals or plant Extracts | Antiaris toxicaria | |
| Geographical availability | Andaman Is., Angola, Benin, Bismarck Archipelago, Borneo, Burkina, Burundi, Cambodia, Cameroon, Central African Repu, Chad, China South-Central, China Southeast, Congo, Ethiopia, Gabon, Gambia, Ghana, Guinea, Guinea-Bissau, Gulf of Guinea Is., Hainan, India, Ivory Coast, Jawa, Kenya, Laos, Lesser Sunda Is., Liberia, Madagascar, Malaya, Mali, Maluku, Myanmar, New Guinea, Nigeria, Northern Territory, Queensland, Rwanda, Santa Cruz Is., Senegal, Sierra Leone, Solomon Is., Sri Lanka, Sudan, Sulawesi, Sumatera, Tanzania, Thailand, Togo, Uganda, Vanuatu, Vietnam, Yemen, Zambia, Zaïre | |
| Plant parts | Stem | |
| Other cancers | Breast cancer, Prostate cancer, Colon cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 3920 nM against MCF-7 | |
| Potency | NA | |
| Cell line/ mice model | KB, HCT-116, SF-268, MCF-7, HL-60, PC-3, MRC-5 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:850341-1 | |
| Safety | NA |