| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1196 | |
| Phytochemical name or plant extracts | Torilis japonica extract (TJE) | |
| PMID | 25051266 | |
| Literature evidence | Torilis japonica extract, a new potential EMT suppressor agent by regulation of EGFR signaling pathways. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Torilis japonica | |
| Geographical availability | Afghanistan, Albania, Assam, Austria, Baleares, Baltic States, Belarus, Belgium, Bulgaria, Central European Rus, China North-Central, China South-Central, China Southeast, Corse, Czechoslovakia, Denmark, East European Russia, East Himalaya, France, Germany, Great Britain, Greece, Hungary, Inner Mongolia, Iran, Ireland, Italy, Japan, Korea, Krym, Kuril Is., Myanmar, Nepal, Netherlands, North Caucasus, Northwest European R, Norway, Pakistan, Palestine, Poland, Portugal, Primorye, Romania, South European Russi, Spain, Sweden, Switzerland, Tibet, Transcaucasus, Turkey, Turkey-in-Europe, Ukraine, Vietnam, West Himalaya, Yugoslavia | |
| Plant parts | Whole Fruits | |
| Other cancers | Breast cancer | |
| Target gene or protein | EGFR, EMT | |
| Gene or Protein evidence | Using specific inhibitors and siEGFR, it was demonstrated that TJE suppressed EMT through EGFR inactivation and regulation of its downstream signaling pathways. | |
| Target pathways | TJE downregulates EGFR activation and both its downstream pathways, the Erk MAP kinase and Akt signaling pathways. | |
| IC50 | NA | |
| Potency | We suggest that TJE is a new potential reagent for EGFR-targeted therapy and anti-abnormal metastasis in MCF-7 breast cancer. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Also TJE treatment results in suppression of EGF-induced EMT by inducing the cell adherent related gene E-cadherin and decreasing mesenchymal markers with the E-cadherin suppressor gene. | |
| PubChem ID | NA | |
| Additional PMIDs | 9619115 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:849533-1 | |
| Safety | NA |