| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1645 | |
| Phytochemical name or plant extracts | Tocotrienol-gamma + Nobiletin | |
| PMID | 24394652 | |
| Literature evidence | In addition, it was found that combinations of tocotrienols with Tamoxifen, a drug widely used for treatment of breast cancer, inhibit these cells more effectively than either tocotrienols or Tamoxifen alone. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Tocotrienol + Flavonoid | |
| Source of phytochemicals or plant Extracts | Palm oil and Tangerine respectively | |
| Geographical availability | NA | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 0.5 μg/mL against MDA-MB-435 0.8 μg/mL against MCF-7 | |
| Potency | These results suggest that diets containing palm oil may reduce the risk of breast cancer, particularly when eaten with other plant foods containing flavonoids, and may also enhance the effectiveness of Tamoxifen for treatment of breast cancer. | |
| Cell line/ mice model | MDA-MB-435, MCF-7 | |
| Additional information | The present studies have now shown synergistic effects between tocotrienols and a number of other flavonoids from various plant sources, including citrus fruits, in the inhibition of both MDA-MB-435 and MCF-7 cells (IC50s 0.05-25 and 0.02-5 μg/mL respectively). | |
| PubChem ID | 5282349 | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |