| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-947 | |
| Phytochemical name or plant extracts | Tinospora cordifolia extract | |
| PMID | 27814592 | |
| Literature evidence | The inevitable development of chemoresistance and unmanageable side effects are the major therapeutic challenges in management of breast cancer imposing an urgent need for identification of novel therapeutic agents. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Chloroform fraction | |
| Source of phytochemicals or plant Extracts | Tinospora cordifolia | |
| Geographical availability | Andaman Is., Assam, Bangladesh, East Himalaya, India, Maldives, Myanmar, Nicobar Is., Sri Lanka, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | TcCF treatment increased intra-cellular ROS levels, altered expression of pro and anti-apoptotic genes, decreased colony formation ability and induced apoptosis in breast cancer cells. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | We also found that inhibition of ROS abrogated TcCF induced apoptosis in breast cancer cells, emphasizing the role ROS in TcCF induced breast cancer cell death. | |
| Cell line/ mice model | MDA-MB-231 and MCF-7 | |
| Additional information | These data show TcCF is a promising anti-cancer agent against breast cancer cells. | |
| PubChem ID | NA | |
| Additional PMIDs | 27814592 28068628 31201865 31696033 24453828 30166229 30543781 28717943 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:907828-1 | |
| Safety | NA |