| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1799 | |
| Phytochemical name or plant extracts | Timosaponin AIII | |
| PMID | 23878598 | |
| Literature evidence | HGF was found to induce c-MET activation and ERK activation, together with increased COX2 protein expression, these changes were followed by a subsequent increase in invasive activity. | |
| IUPAC name | (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[(1R,2S,4S,5'S,6R,7S,8R,9S,12S,13S,16S,18R)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-oxane]-16-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Anemarrhena asphodeloidea Bunge | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Inner Mongolia, Manchuria, Mongolia | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | COX2, c-met, MMP9, ERK | |
| Gene or Protein evidence | TAIII was found to suppress HGF-induced invasive activity and COX2 gene expression in a concentration-dependent manner (10(-6)~10(-8) M) in parallel with increases in the phosphoforms of c-Met and ERK after TAIII treatment. The mechanisms by which TAIII suppresses HGF-induced invasive activity were demonstrated to include sustained cytoplasmic and nuclear ERK activation, these led to a suppression of nuclear ATF2 activation, which was followed by downregulation of COX2 and MMP-9 transcription. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | TAIII suppresses HGF-induced invasive activity in MDA-MB-231 cells via sustained ERK activation. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | TAIII was found to suppress HGF-induced invasive activity and COX2 gene expression in a concentration-dependent manner (10(-6)~10(-8) M) in parallel with increases in the phosphoforms of c-Met and ERK after TAIII treatment. | |
| PubChem ID | 15953793 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:530140-1 | |
| Safety | NA |