| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-782 | |
| Phytochemical name or plant extracts | Thymol | |
| PMID | 32115964 | |
| Literature evidence | Apoptotic effects of thymol, a novel monoterpene phenol, on different types of cancer. | |
| IUPAC name | 5-methyl-2-propan-2-ylphenol | |
| Phytochemicals’ class or type of plant extracts | Phenol | |
| Source of phytochemicals or plant Extracts | Xylopia sericea | |
| Geographical availability | Bolivia, Brazil North, Brazil Northeast, Brazil South, Brazil Southeast, Brazil West-Central, Colombia, Costa Rica, Ecuador, French Guiana, Guyana, Nicaragua, Panamá, Peru, Suriname, Venezuela | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Prostate cancer, Lung cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 208.36 μM against MDA-MB-231 at 72h | |
| Potency | According to our data, thymol shows concentration- and time-dependent antiproliferative and apoptotic effects on non-small cell lung cancer, prostate cancer and highly metastatic human breast cancer cell lines. Not only does thymol inhibit proliferation, it also induces apoptosis in cancer cells. | |
| Cell line/ mice model | MDA-MB-231, PC-3, DU145, KLN205 | |
| Additional information | Thymol significantly induced apoptosis in all groups in a dose-dependent manner. Statistical analysis showed a significant difference between thymol‑treated cell lines compared to the control (p < 0.001). | |
| PubChem ID | 6989 | |
| Additional PMIDs | 32115964 32532265 32748632 27793897 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:76256-1 | |
| Safety | NA |