| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2162 | |
| Phytochemical name or plant extracts | Thymbra Spicata extract | |
| PMID | 32696667 | |
| Literature evidence | The ethanolic extract significantly inhibited proliferation of different human tumor cell lines, without significant effects on non-neoplastic cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Thymbra Spicata | |
| Geographical availability | East Aegean Is., Greece, Iran, Iraq, Lebanon-Syria, Palestine, Turkey, Turkey-in-Europe | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer | |
| Target gene or protein | STAT-3, NF-kB | |
| Gene or Protein evidence | The effects on MCF-7 cells were associated with the following: (i) production of reactive oxygen species (ROS) and release of nitric oxide; (ii) apoptosis induction; and (iii) reduction in STAT3 and NF-kB phosphorylation. | |
| Target pathways | STAT3, and NF-kB Signaling | |
| IC50 | NA | |
| Potency | The ethanolic extract significantly inhibited proliferation of different human tumor cell lines, without significant effects on non-neoplastic cells. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | The ethanolic extract from T. spicata leaves might represent a novel therapeutic tool in combination with conventional chemotherapy to reduce the adverse side effects and drug resistance. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:460827-1 | |
| Safety | NA |