| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-108 | |
| Phytochemical name or plant extracts | Thidiazuron | |
| PMID | 33159487 | |
| Literature evidence | Thidiazuron (TDZ) is a novel plant growth regulator that has been shown to have anticancer effects. | |
| IUPAC name | 1-phenyl-3-(thiadiazol-5-yl)urea | |
| Phytochemicals’ class or type of plant extracts | Plant growth regulator | |
| Source of phytochemicals or plant Extracts | Nymphaea alba | |
| Geographical availability | Albania, Algeria, Austria, Baleares, Baltic States, Belarus, Belgium, Bulgaria, Central European Rus, Corse, Czechoslovakia, Denmark, East European Russia, Finland, France, Germany, Great Britain, Greece, Hungary, Iran, Iraq, Ireland, Italy, Lebanon-Syria, Morocco, Netherlands, North Caucasus, North European Russia, Northwest European Russia, Norway, Palestine, Poland, Portugal, Romania, South European Russia, Spain, Sweden, Switzerland, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Ukraine, West Himalaya, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | uPAR, uPA, VEGF, MMP2, MMP9, TIMP-1/2 | |
| Gene or Protein evidence | Additionally, TDZ treatment led to down-regulation of uPAR, uPA, VEGF and MMP-2/-9 expression and up-regulation of TIMP-1/2 expression in these cells. | |
| Target pathways | NF‐kB and PI3K/AKT signalling pathways | |
| IC50 | NA | |
| Potency | Furthermore, TDZ treatment blocked invasion and EMT in non-tumorigenic BEAS-2B epithelial cells stimulated with TGF-β/TNF-α.TDZ prevents EMT and may thus block metastasis of breast cancer cells. | |
| Cell line/ mice model | NA | |
| Additional information | NA | |
| PubChem ID | 40087 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:171158-2 | |
| Safety | NA |