| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-881 | |
| Phytochemical name or plant extracts | Theaflavins | |
| PMID | 18454316 | |
| Literature evidence | However, in the same cells, when p53-mediated transactivation was inhibited by pifithrin-alpha, theaflavins not only failed to increase transcription but also to induce apoptosis although p53 up-regulation was not altered. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Black tea | |
| Geographical availability | Assam, China South-Central, China Southeast, East Himalaya, Hainan, Laos, Myanmar, Thailand, Vietnam | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | p53, Bax | |
| Gene or Protein evidence | Apoptogenic effect was more pronounced in functional p53-expressing cells in which theaflavins raised p53 protein levels that harmonized with Bax up-regulation and migration to mitochondria. | |
| Target pathways | p53 transcription-dependent pathway | |
| IC50 | NA | |
| Potency | Together these findings suggest that in breast cancer cells, p53 promotes theaflavin-induced apoptosis in a transcription-dependent manner through mitochondrial death cascade. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, ZR-75-1 | |
| Additional information | In contrast, Bax over-expression restored back theaflavin-induced apoptosis in pifithrin-alpha-inhibited/dominant-negative p53-expressing cells. Inhibition of Bax by RNA-interference also reduced theaflavin-induced apoptosis. | |
| PubChem ID | 114777 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:828548-1 | |
| Safety | NA |