| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1902 | |
| Phytochemical name or plant extracts | Tetrandrine (Tet) | |
| PMID | 28642707 | |
| Literature evidence | This study aims to identify novel traditional Chinese medicinal herbs as potential anti-tumor agents through autophagic induction, which finally lead to autophagy mediated-cell death in apoptosis-resistant cancer cells. | |
| IUPAC name | (1S,14S)-9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaene | |
| Phytochemicals’ class or type of plant extracts | Isoquinolines | |
| Source of phytochemicals or plant Extracts | Radix stephaniae tetrandrae | |
| Geographical availability | NA | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | Therefore, the present study suggests the apoptosis of cells with the activation of caspase pathways mainly intrinsic pathway as a downstream event of tetrandrine-induced ROS generation. | |
| IC50 | NA | |
| Potency | Hence, reactive oxygen species-mediated caspase activation pathway may be potentially targeted with the use of tetrandrine to treat breast and pancreatic cancers. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | Taken together, this study supported the fact that TET is a promising therapeutic agent for the treatment of TNBC, thereby providing experimental evidence for its use in the treatment of breast cancer. | |
| PubChem ID | 73078 | |
| Additional PMIDs | 30945115 28642707 32714412 | |
| Additional sources of information | NA | |
| Safety | acute toxic in pubchem database |