| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1134 | |
| Phytochemical name or plant extracts | Tetramethoxystilbene | |
| PMID | 31004704 | |
| Literature evidence | In addition, TMS activated the AHR more potently (EC50 in a reporter gene assay 2.0 μM) and induced AHR-mediated induction of cytochrome P450 1A1 (CYP1A1) activity (EC50 value of 0.7 μM) more than resveratrol and the other analogues tested. | |
| IUPAC name | 1-[(E)-2-(2,4-dimethoxyphenyl)ethenyl]-3,5-dimethoxybenzene | |
| Phytochemicals’ class or type of plant extracts | Stilbene | |
| Source of phytochemicals or plant Extracts | Maclura pomifera | |
| Geographical availability | Arkansas, Oklahoma, Texas | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | CYP1A1 , CYP1B1, Nqo1 , IL-8 | |
| Gene or Protein evidence | Gene expression analysis showed that 3 μM TMS increased gene expression of CYP1A1 (289-fold), CYP1B1 (5-fold) and Nqo1 (2-fold), and decreased gene expression of IL-8 (3-fold) in MCF-7 cells. | |
| Target pathways | NA | |
| IC50 | TMS exhibited stronger CYP1A1 and CYP1B1 inhibitory properties with previously reported IC50 values of 300 nM and 6 nM respectively. | |
| Potency | In addition, TMS activated the AHR more potently (EC50 in a reporter gene assay 2.0 μM) and induced AHR-mediated induction of cytochrome P450 1A1 (CYP1A1) activity (EC50 value of 0.7 μM) more than resveratrol and the other analogues tested. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | NA | |
| PubChem ID | 5354004 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:148738-2 | |
| Safety | NA |